I was diagnosed Type 2 some 6-7 years ago. Initially on Metformin I progressed to a variety of additional oral meds (only one type at a time) until settling on Diamicron (gliclazide) which is one of those meds which will burn out my pancreas eventually. I was also on Byetta - First 5, good response, then 10, better response, but the nausea got to me, doc dropped the dose back to 5 but it was no good, BGLs went up and nausea did not quit. I stopped it two months ago. Initial response to stopping it was rebound hyperglycaemia (well thats what I am calling it anyway) but in the last month I was starting to get some control.
My endo has agreed that it is worth adding another oral (Actos) and see how its going in 3 months. I'm only two weeks down the track and my morning readings have been in normal - low range (not hypo). Throughout the day it varies, but unless I am "bad" (which I still am from time to time) all my readings are remaining within the target range. I'm expecting that, given my response, the overall readings will continue to reduce and therefore I will be asking to reduce the Diamicron when I go for my next visit. I'm still puzzling why Actos has never been prescribed before. Its good, no nausea, and it tends to deal with the after meal spike, flattening it somewhat.
Byetta was certainly most excellent in getting my BGLs back into a normal range... but the nausea was horrid. Just one of those drugs not everyone can take.
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