I'm still in the experimental stages of trying to find the right dosage of metformin and if I can tolerate the higher doses. At the lower doses of the instant release I have had success over the period of two months when taken during supper. Then I was given a combination of metformin and Januvia extended release, called Janumet XR, at a higher dose (100/1000) and began to have problems with gas buildup in my lower G.I. and the feeling of my lower intestines being packed full. A very uncomfortable feeling. I'm now going to go back to attempt the 500mg metformin instant release twice a day. I think the extended release in the Janumet was the problem.
Metformin is effective in lowering my glucose levels so I would really like to find a form and dose that I can tolerate.
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