From what I have heard there is an extended release (XR) version of metformin that is supposed to be easier on the stomach. Also, they say that the gastrointestinal side effects often decrease or disappear over time (not that this is very comforting when you're suffering with them).
If it were me I would discuss the problem with my doctor and explore options to try and make the metformin more manageable for you as it is a very effective and well understood medicine.
As for the depressed feelings, well simply getting the diagnosis of diabetes is enough to cause depression in a lot of people. Again I would talk to your doctor about your emotional well-being. You may need help such as counseling or anti-depressant medication to help you adjust to your circumstances. I've noticed that the more I learn about diabetes and the more success I have managing my blood sugar the less depressed I feel.
Finally, about the irregular cycle, only your doctor can tell you for sure what's going on there and whether or not it might be related to taking metformin. Everyone's body reacts differently and it may be stress or elevated blood sugar or medication or any number of other factors that are affecting your cycle.
Good luck!
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